Cover
Vol. 1 No. 1 (2022)

Published: December 21, 2022

Pages: 25-31

Original Article

Medical Application of Graphene and its derivative

Ahmed Jassim Muklive Al-Ogaidi 1 Firas Al-Oqaili Liblab S. Jassim Shaymaa S. Hassan Hamssa Ahmed Easa
1The University of Technology, Iraq
History
  • Received: November 1, 2022
  • Accepted: November 24, 2022
  • Available Online: December 21, 2022

Abstract

Graphene is one of the most important compounds that possess a lot of very unique chemical properties. The importance of graphene and its diverse medical use in all directions has increased, making this matter the focus of attention and attention of scientists and medical specialists with regard to the early diagnosis of cancer and tumors, its clinical follow-up and treatment, especially in recent years. In this review, the medical and pharmacological applications and uses of graphene in the early diagnosis of different types of cancer and how to follow up on disease cases were discussed. The most important difficulties facing researchers in the applied medical field of graphene were also discussed. The important and exceptional feature of graphene composite was the influential point in the diversity of medical applications of graphene, including electronic superconductivity, very high surface area, thermal conductivity, mechanical strength, low economic cost, and possible development methods .A deep and comprehensive understanding of the interactions of graphene, which include organs and tissues, could lead to the production or formation of nano platforms such as graphene oxide that are more productive than graphene, Which has shown many important achievements regarding the applications of medical sensors that were in their initial stages.

References

  1. Novoselov KS, Geim AK, Morozov SV. Electric field effect in atomically thin carbon films. Science. 2018;306(5696):666–669.
  2. Zhang K, Zhang LL, Zhao XS. Graphene-polyaniline nanofiber composites as supercapacitor electrodes. Chem Mater. 2019;22(4):1392–1401.
  3. Xuan Y, Wu YQ, Shen T. Atomic-layer-deposited nanostructures for graphene-based nano electronics. Appl Phys Lett. 2018;92(1):013101–3.
  4. Yang XM, Tu YF, Li L. Well-dispersed chitosan/graphene oxide nanocomposites. ACS Appl Mater Interfaces. 2019;2(6):1707–1713.
  5. Liu C, Alwarappan S, Chen ZF. Membraneless enzymatic biofuel cells based on graphene nanosheets. Biosens Bioelectron. 2020;25:1829–1833.
  6. Lu CH, Yang HH, Zhu CL. A graphene platform for sensing biomolecules. Angew Chem Int Ed. 2019;121(26):4879–4881.
  7. Qu LT, Liu Y, Baek JB. Nitrogen-doped graphene as efficient metal-free electrocatalyst for oxygen reduction in fuel cells. ACS Nano. 2019;4(3):1321–1326.
  8. Liu Z, Robinson JT, Sun XM. PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc. 2018;130(33):10876–10877.
  9. Guo SJ, Dong SJ. Graphene nanosheet: synthesis, molecular engineering, thin film, hybrids, and energy and analytical applications. Chem Soc Rev. 2021;40(5):2644–2672.
  10. Hummers WS, Offeman RE. Preparation of Graphitic Oxide. J Am Chem Soc. 2017;80:1339–1339.
  11. Dai HJ. Carbon nanotubes: opportunities and challenges. Surface Sci. 2002;500:218–241.
  12. Yang ZR, Wang HF, Zhao J. Recent developments in the use of adenoviruses and immunotoxins in cancer gene therapy. Cancer Gene Ther. 2017;14:599–615.
  13. Naldini L, Blömer U, Gallay P. In Vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 2016;272:263–267.
  14. Mintzer MA, Simanek EE. Nonviral vectors for gene delivery. Chem Rev. 2019;109(2):259–302.
  15. Yang K, Zhang S, Zhang GX. Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 2020;10(9):3318–3323.
  16. Tang LH, Wang Y, Li YM. Preparation, structure and electrochemical properties of graphene modified electrode. Adv Funct Mater. 2019;19(17):2782–2789.
  17. Wang Y, Shao YY, Matson DW. Nitrogen-doped graphene and its application in electrochemical biosensing. ACS Nano. 2020;4(4):1790–1798.
  18. Chang HX, Tang LH, Wang Y. Graphene fluorescence resonance energy transfer aptasensor for the thrombin detection. Anal Chem. 2019;82(6):2341–2346.
  19. Wang Y, Li ZH, Hu DH. Aptamer/graphene oxide nanocomplex for in situ molecular probing in living cells. J Am Chem Soc. 2018;132(27):9274–9276.
  20. Tang LH, Wang Y, Liu Y. DNA-directed self-assembly of graphene oxide with applications to ultrasensitive oligonucleotide assay. ACS Nano. 2017;5(5):3817–3822.
  21. Dong XL, Cheng JS, Li JH. Graphene as a novel matrix for the analysis of small molecules by MALDI-TOF MS. Anal Chem. 2018;82(14):6208–6214.
  22. Wang Y, Li YM, Tang LH. Application of graphene modified electrode for selective detection of dopamine. Electrochem Commun. 2019;11(4):889–892.
  23. Peng C, Hu WB, Zhou YT. Intracellular imaging with a graphene-based fluorescent probe. Small. 2019;6(15):1686–1692.
  24. Pan DY, Zhang JC, Li Z. Hydrothermal route for cutting graphene sheets into blue-luminescent graphene quantum dots. Advan Mater. 2019;22(6):734–738.
  25. Takeda A, Oku T, Suzuki A, Akiyama T, Yamasaki Y. Fabrication and Characterization of Fullerene based Solar Cells Containing Phthalocyanine and Naphthalocyanine Dimers. Synthetic Metals. 2013;177:48–51.
  26. Simon J, Sirlin C. Mesomorphic molecular materials for electronics, opto-electronics, iono-electronics: Octaalkyl- phthalocyanine derivatives. Pure Applied Chemistry. 1989;61:1625–1629.
  27. Guillaud G, Simon J, Germain JP. Metallophthalocyanines: Gas sensors, resistors and field effect transistors. Coordination Chemistry Reviews. 1998;178:1433–1483.
  28. Meunier B. Metalloporphyrins as versatile catalysts for oxidation reactions and oxidative DNA cleavage. Chemistry Reviews. 1992;92:1411–1456.
  29. Sehlotho N, Nyokong T. Zinc Phthalocyanine photocatalyzed oxidation of cyclohexene. J Mol Catalysis A: Chemical. 2004;219:201–207.
  30. Tu W, Lei J, Zhang HS, Ju H. Novel Graphene-Based Nanostructures Production, Functionalization, and Engineering. Chemistry. 2010;16:10771–10777.
  31. Stojek Z. Pulse voltammetry. In: Scholz F (Ed.), Electroanalytical Methods. Springer, Berlin/Heidelberg/New York; 2001, chap. II.
  32. Qiu S, Li X, Xiong W, Xie L, Guo L, Lin Z, Qiu B, Chen G. A novel fluorescent sensor for mutational p53 DNA sequence detection based on click chemistry. Biosens Bioelectron. 2013;41:403–408.
  33. Du D, Wang L, Shao Y, Wang J, Engelhard MH, Lin Y. Functionalized graphene oxide as a nanocarrier in a multienzyme labeling amplification strategy for ultrasensitive electrochemical immunoassay of phosphorylated p53 (S392). Analytical Chemistry. 2011;83:746.
  34. Xie Y, Chen A, Du D, Lin Y. Graphene-based immunosensor for electrochemical quantification of phosphorylated p53 (S15). Analytica Chimica Acta. 2011;699:44.
  35. Hamidi-Asl E, Raoof JB, Ojani R, Hejazi MS. Indigo carmine as new label in PNA biosensor for detection of short sequence of p53 tumor suppressor gene. Electroanalysis. 2013;25:2075.
  36. Wang X, Zhang X, He P, Fang Y. Sensitive detection of p53 tumor suppressor gene using an enzyme-based solid-state electrochemiluminescence sensing platform. Biosensors and Bioelectronics. 2011;26:3608.
  37. Chen A, Bao Y, Ge X, Shim Y, Du D, Lin Y. Magnetic particle-based immunoassay of phosphorylated p53 using protein cage templated lead phosphate and carbon nanospheres for signal amplification. Royal Society of Chemistry. 2012;2:11029.
  38. Wang X, Wang X, Wang X, Chen F, Zhu K, Xu Q, Tang M. Novel electrochemical biosensor based on functional composite nanofibers for sensitive detection of p53 tumor suppressor gene. Analytica Chimica Acta. 2013;765:63.
  39. Chen X, He C, Zhang Z, Wang J. Sensitive chemiluminescence detection of wild-type p53 protein captured by surface-confined consensus DNA duplexes. Biosensors and Bioelectronics. 2013;47:335.
  40. Li H, Wu Z, Qiu L, Liu J, Wang C, Shen G, Yu R. Ultrasensitive label-free amplified colorimetric detection of p53 based on G-quadruplex MBzymes. Biosensors and Bioelectronics. 2013;50:180.
  41. Hadi A, Balal K, Habib T, Mahmood M, Farzaneh N, Mohammad-Reza R. A sandwich type immunosensor for ultrasensitive electrochemical chemical quantification of p53 protein based on gold nanoparticles/graphene oxide. Electrochimica Acta. 2016;188:153–164.
  42. Al-Ogaidi AJM, Razzak AA, Mohammed MAH. Adsorption of Oils Pollutants by Using Nano Materials. NeuroQuantology. 2021;19(10):8–1. doi: 10.14704/nq.2021.19.10.NQ21150
  43. Al-Ogaidi AJM, Stefan-Van Staden RI, Gugoasa LA, Van Staden JF, Yanik H, Göksel M, Durmuş M. A new potentiometric sensor for the assay of p53 in blood samples. U.P.B. Sci. Bull. Series B. 2017;79(2):113–120.
  44. Al-Ogaidi AJM, Stefan-van Staden RI, Gugoasa LA, Rosu MC, Socaci C. Electrochemical determination of the KRAS genetic markers for colon cancer with modified graphete and graphene paste electrodes. Analytical Letters. 2018;51(17):2820–2832. doi: 10.1080/00231772.2018.1465225.
  45. Mohammed MA, Al-Ogaidi AJM, Kamil GM. Micro determination of tyrosine by spectrophotometric techniques. International Journal of Medical Toxicology and Legal Medicine. 2021;24(3-4):308–311. doi: 10.5958/0974-4614.2021.00099.1.
  46. Al-Ogaidi AJM, Qasim B, Hamid DM, Mohammed AAR. Ultra higher assessment of tyrosine compounds by coupling for biological samples. Annals of Tropical Medicine & Public Health. 2020;23(19):SP232112. doi: 10.36295/ASRO.2020.232112.