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Go to Editorial ManagerMitoxantrone is a chemotherapeutic very effective against a variety of human malignancies Administration of Mitoxantrone is associated with hepatotoxicity Zinc has protective effect in liver illness. This study aimed to determine the role of zinc gluconate as a hepatoprotective agent in Mitoxantrone induced hepatotoxicity in rats. Methods there were twenty-four male and female rats used. Rats were divided up Into three groups, each consisting of eight animals. Distilled water is in Group I (negative control).Group II Mitoxantrone was delivered intraperitoneally with a dosage of 2.50 mg/ kg in order to achieve a cumulative complete dosage of 7.50 mg /kg by day 20. Group III Zinc gluconate was orally provided at a dosage of 20 mg/ kg/day, and Mitoxantrone was injected intraperitoneally at a rate of 2.50 mg/kg. The goal was to attain a cumulative total dosage of 7.50mg/ kg by day 20.After 48 hours following the completion of the treatment period, diethyl ether was used to euthanize each animal (i.e., on day 22). Serum was used to determine the activity of the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes.Each animal's liver was removed in order to perform a terminal deoxynucleotidyl-transferase-mediated-deoxyuridine-triphosphate, necked labeling (TUNEL) test to detect DNA fragmentation. Results Zinc gluconate significantly (P<0.05) decreased blood ALT and AST, and group III showed a higher percentage of normal hepatocyte cells and a lower percentage of apoptotic cells than group II. Conclusions Zinc gluconate may have a protective effect against the hepatotoxicity induced by Mitoxantrone in rats.
Background: Lifestyle medicines (LSMs) are used to help people alter their lifestyles. These medicines are used for purposes other than medicine or health. Aims & Objectives: The objective of the study was to evaluate the prevalence of LSM use among the students of the university, the rationale for their utilization, and the kinds of consequences, in order to give useful data for reasoning and prevention of this problem. Method: A cross-sectional descriptive research study was carried out. university students in Wasit, Iraq, by using a self-administered questionnaire. Participants were usefully recruited through online platforms. The questionnaire consist of four sections, including sociodemographic profile, knowledge, and awareness in a validated questionnaire format. Results: A total of 500 students aged between 18-25 and more were surveyed. The number who utilize LSMs was 470(94%). The most common agents utilized by a high number of students were vitamins 136(28.94%) followed by Non-steroidal anti-inflammatory drugs 41(8.72%), then caffeine-containing substances 38(8.09% ). The most frequent adverse effects related to use of LSMs were lethargy and fatigue and 68 (14.47%), and insomnia 41(8.72%). Conclusion: Awareness of Lifestyle Medications (LSMs) was moderate, with medical advice being the primary source of information. The study found a high prevalence of LSM use, with vitamins being the most commonly used. Adverse effects varied among users, with fatigue and the lethargy being the most reported. Despite diverse perceptions toward LSMs, a significant differences in awareness were noted based on gender and study field, highlighting the need for targeted education and intervention strategies.