Moringa is a natural and cultivated variety of the genus Moringa of the family Moringaceae. The cultivation of Moringa is widespread due to multiple medicinal and healing properties. It is one of the richest plant sources of Vitamins A, B , C, D, E, K , in addition to proteins and minerals .The recent study aimed to phytochemically analyze Moringa oleifera grown in Iraqi environment and detection of some active compounds of the plant. Research reported that Moringa can support a healthy cardiovascular system, promote normal blood glucose levels, neutralize free radicals, provide excellent support of the body's anti inflammatory mechanisms, enrich anemic blood and support immune system. Moringa oleifera contains various phytoconstituents which contribute to its therapeutic uses such as alkaloids, saponins, tannins, steroids, phenolic acids, glycosides, flavonoids, and terpenoids. This study was able to identify the different phytochemical compounds present in Moringa cultivated in Iraq using preliminary chemical tests and to identify the presence of Quercetin using high performance liquid chromatography (HPLC) and thin layer chromatography (TLC). The chromatographic techniques proved the presence of Quercetin by showing identical retention time and retention factor almost identical to that produced by quercetin standard.
The protective reaction of an organism to potentially harmful stimuli is known as inflammation, and it can result from a variety of sources, including physical, chemical, or viral injuries. A large number of people in our society suffer from long-term inflammatory diseases, which makes it necessary to constantly develop new anti-inflammatory drugs. The development of powerful anti-inflammatory medications has advanced significantly in recent years. As a result, heterocyclic compounds made up a sizeable fraction of organic chemistry due to their pharmacological activity and distinct physical traits that distinguished them from other cyclic compounds. One of the most common N-based heterocyclic molecules is imidazolidine. Numerous scientists have become interested in it because of the variety of industrial and pharmacological uses. In the present study, the work dedicated to designed new imidazolidine derivatives. Molecular Docking Software (Schrodinger) was used to check the binding interaction between new derivatives (4N, 4M, 4D, 4In, 4Ib) and the cyclooxygenase active site of COX-2 in comparison with naproxen, mefenamic acid, diclofenac, indomethacin and ibuprofen as references drugs respectively. The results demonstrated that good binding affinity achieved by all new compounds with the exception of 4D derivative in comparison with diclofenac. Finally, the findings of the ADME study demonstrated that all new derivatives met the Lipinski rule of five and expected to be highly absorbed from gastrointestinal tract.