Cover
Vol. 2 No. 2 (2024)

Published: August 31, 2024

Pages: 82-92

Original Article

The correlation of thyroid function with obesity

Abstract

The thyroid is an endocrine gland. It controls the body's iodine balance as well as the creation and release of thyroid hormones from its location in the inferior, anterior neck. The thyroid produces both triiodothyronine, which is mostly active, and thyroxine (T4), which is primarily dormant (T3). Thyroid hormone that has undergone peripheral conversion is either activated thyroid hormone or another inactive thyroid hormone. Body composition and thyroid hormones appear to be closely related. Thyroid hormones regulate basal metabolism, thermogenesis and play an important role in lipid and glucose metabolism, food intake and fat oxidation. Thyroid dysfunction is associated with changes in body weight and composition, body temperature and total and resting energy expenditure (REE) independent of physical activity. The hypothalamic-pituitary-thyroid axis is more likely to be activated in obese patients with healthy thyroid function and greater blood levels of thyroid hormones. On the other hand, slight variations in thyroid function are linked to weight changes of up to 5 kg. An online survey was conducted in Al_Nahrain university college of pharmacy. The aim of this survey is to find the correlation between thyroid function and obesity in the Iraqi population who are diagnosed and treated of hypothyroidism. Current study outcomes is to find the correlation between thyroid function and obesity in the Iraqi population who are diagnosed and treated of hypothyroidism. The correlation between BMI and TSH showed elevattion 4.5-10 mIU/mL, 36 had severely Elevated > 10 mIU/mL while 9 are normal 0.5-4.5 mIU/mL. Aim: The aim of this survey is to find the correlation between thyroid function and obesity in the Iraqi population who are diagnosed and treated of hypothyroidism.

References

  1. Khalifa A, Alotaibi A, Albahlal A, et al. General public awareness about symptoms and risk factors of cardiovascular diseases in Riyadh city, Saudi Arabia. IJMDC. 2019;3:44–51.
  2. Abdulrahman Ibrahim AM. Survey of awareness of thyroid disorders among the Riyadh population, Central Region of Saudi Arabia. Egypt J Hosp Med. 2018;72:4039–4044.
  3. Vanderpump MP. Epidemiology of Thyroid Dysfunction - Hypothyroidism and Hyperthyroidism. In: Thyroid International. Vol. 2. Darmstadt: Thyroid International; 2009. pp. 1–12.
  4. Vanderpump MP. Epidemiology of Thyroid Dysfunction – Hypothyroidism and Hyperthyroidism. In: Thyroid International. Vol. 2. Darmstadt: Thyroid International; 2009. pp. 1–12.
  5. Vanderpump MP. The epidemiology of thyroid disease. Br Med Bull. 2011;99:39–51.
  6. Zelmanovitz F. Screening for thyroid disease. Ann Intern Med. 1999;130:161.
  7. Alam Khan V, Khan MA, Akhtar S. Thyroid disorders, etiology and prevalence. J Med Sci. 2002;2:89–94.
  8. Cooper DS, Biondi B. Subclinical thyroid disease. Lancet. 2012;379:1142–54.
  9. Salerno M, Capalbo D, Cerbone M, De Luca F. Subclinical hypothyroidism in childhood—current knowledge and open issues. Nat Rev Endocrinol. 2016;12:734–46.
  10. Persani L. Clinical review: Central hypothyroidism: pathogenic, diagnostic, and therapeutic challenges. J Clin Endocrinol Metab. 2012;97:3068–78.
  11. Panicker V, Wilson SG, Spector TD, et al. Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort. Clin Endocrinol. 2008;68:652–59.
  12. Asvold BO, Bjøro T, Nilsen TI, Vatten LJ. Tobacco smoking and thyroid function: a population-based study. Arch Intern Med. 2007;167:1428–32.
  13. Beynon J, Akhtar S, Kearney T. Predictors of outcome in myxoedema coma. Crit Care. 2008;12:111.
  14. Wiersinga WM. Myxedema and coma (severe hypothyroidism). In: De Groot LJ, Chrousos G, Dungan K, et al., eds. Endotext. South Dartmouth, MA: MD Text.com; 2000.
  15. Carlé A, Pedersen IB, Knudsen N, Perrild H, Ovesen L, Laurberg P. Gender differences in symptoms of hypothyroidism: a population-based DanThyr study. Clin Endocrinol. 2015;83:717–25.
  16. Carlé A, Pedersen IB, Knudsen N, et al. Hypothyroid symptoms fail to predict thyroid insufficiency in old people: a population-based case-control study. Am J Med. 2016;129:1082–92.
  17. Canaris GJ, Steiner JF, Ridgway EC. Do traditional symptoms of hypothyroidism correlate with biochemical disease? J Gen Intern Med. 1997;12:544–50.
  18. Jonklaas J, Bianco AC, Bauer AJ, et al., for the American Thyroid Association Task Force on Thyroid Hormone Replacement Study Group.
  19. Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association Task Force on thyroid hormone replacement. Thyroid. 2014;24:1670–751.
  20. Roos A, Linn-Rasker SP, van Domburg RT, Tijssen JP, Berghout A. The starting dose of levothyroxine in primary hypothyroidism treatment: a prospective, randomized, double-blind trial. Arch Intern Med. 2005;165:1714–20.
  21. Pearce SHS, Brabant G, Duntas LH, et al. 2013 ETA Guideline: management of subclinical hypothyroidism. Eur Thyroid J. 2013;2:215–28.
  22. Abdalla SM, Bianco AC. Defending plasma T3 is a biological priority. Clin Endocrinol. 2014;81:633–41.
  23. Alexander EK, Marqusee E, Lawrence J, Jarolim P, Fischer GA, Larsen PR. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. N Engl J Med. 2004;351:241–9.
  24. Stagnaro-Green A, Abalovich M, Alexander E, et al., for the American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum Study Group. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21:1081–125.
  25. Rosenbaum M, Hirsch J, Murphy E, Leibel RL. Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function. Am J Clin Nutr. 2000;71:1421–32.
  26. Danforth E Jr, Horton ES, O'Connell M, Sims EA, Burger AG, Ingbar SH, et al. Dietary-induced alterations in thyroid hormone metabolism during overnutrition. J Clin Invest. 1979;64:1336–47.
  27. Knudsen N, Laurberg P, Rasmussen LB, Bülow I, Perrild H, Ovesen L, et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab. 2005;90:4019–24.
  28. Biondi B. Thyroid and obesity: An intriguing relationship. J Clin Endocrinol Metab. 2010;95:3614–7.
  29. Reinehr T, de Sousa G, Andler W. Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. J Clin Endocrinol Metab. 2006;91:3088–91.
  30. Lambrinoudaki I, Armeni E, Rizos D, et al. Indices of adiposity and thyroid hormones in euthyroid postmenopausal women. Endocrinol. 2015;173:237–45.
  31. Santini F, Marzullo P, Rotondi M, et al. Mechanisms in endocrinology: the crosstalk between thyroid gland and adipose tissue: Signal integration in health and disease. Eur J Endocrinol. 2014;171:R137–52.
  32. Pearce EN. Thyroid hormone and obesity. Curr Opin Endocrinol Diabetes Obes. 2012;19:408–13.
  33. Fontenelle LC, Feitosa MM, Severo JS, et al. Thyroid function in human obesity: underlying mechanisms. Horm Metab Res. 2016;48:787–94.
  34. Muscogiuri G, Sorice GP, Mezza T, et al. High-normal TSH values in obesity: Is insulin resistance or adipose tissue’s guilt. Obesity (Silver Spring). 2013;21:101–6.
  35. Ren R, Jiang X, Zhang X, et al. Association between thyroid hormones and body fat in euthyroid subjects. Clin Endocrinol (Oxf). 2014;80:585–90.
  36. Lips MA, Pijl H, van Klinken JB, et al. Roux-en-Y gastric bypass and calorie restriction induce comparable time-dependent effects on thyroid hormone function tests in obese female subjects. Eur J Endocrinol. 2013;169:339–35.
  37. Nannipieri M, Cecchetti F, Anselmino M, et al. Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: Effects of weight loss. Int J Obes (Lond). 2009;33:1001–6.
  38. Isozaki O, Tsushima T, Nozoe Y, et al. Leptin regulation of the thyroids: Negative regulation on thyroid hormone levels in euthyroid subjects and inhibitory effects on iodide uptake and Na+/I− symporter mRNA expression in rat FRTL-5 cells. Endocr J. 2004;51(4):415–23.
  39. Cabanelas A, Lisboa PC, Moura EG, et al. Acute effects of leptin on 5′deiodinases are modulated by thyroid state of fed rats. Horm Metab Res. 2007;39:818–22.
  40. Cabanelas A, Lisboa PC, Moura EG, et al. Leptin acute modulation of the 5′deiodinase activities in hypothalamus, pituitary and brown adipose tissue of fed rats. Horm Metab Res. 2006;38:481–85.
  41. Araujo RL, Carvalho DP. Bioenergetic impact of tissue-specific regulation of iodothyronine deiodinases during nutritional imbalance. J Bioenerg Biomembr. 2011;43:59–65.
  42. Araujo RL, Andrade BM, Padrón AS, et al. High-fat diet increases thyrotropin and oxygen consumption without altering circulating 3,5,3′-triiodothyronine (T3) and thyroxine in rats: The role of iodothyronine deiodinases, reverse T3 production, and whole-body fat oxidation. Endocrinology. 2010;151:3460–42.
  43. Xu R, Huang F, Zhang S, et al. Thyroid function, body mass index, and metabolic risk markers in euthyroid adults: a cohort study. BMC Endocr Disord. 2019;19:58.
  44. Silva JE. Thyroid hormone control of thermogenesis and energy balance. Thyroid. 1995;5(6):481–92.