Cover
Vol. 4 No. 1 (2026)

Published: June 1, 2026

Pages: 233-244

Research Article

Investigation of the Anti-Angiogenic activity of Anabasis setifera

Nabaa Maher 1 Haydar Baha Sahib 1
1 Department of pharmacology and toxicology, College of Pharmacy, University of Al-Nahrain, Baghdad, Iraq
History
  • Received: March 25, 2026
  • Revised: May 14, 2026
  • Accepted: May 16, 2026
  • Available Online: June 1, 2026

Abstract

Objective  to find the potential anti–angiogenic and antioxidant effect of Anabasis setifera  extracts.  Methods  The rat aortic ring anti-angiogenesis assay, DPPH radical scavenging assay, and chick chorioallantoic membrane (CAM) assay were carried out in the tissue culture laboratory of the Department of Pharmacology, College of pharmacy, Al-Nahrain University. Results The aqueous extract of Anabasis setifera demonstrated significant inhibition of microvessel outgrowth in the rat aortic ring assay by 71% , with 86.5%  reduction of blood vessels growth In the CAM model, treatment resulted in a marked reduction in neovascularization compared with the control group. The extract also exhibited concentration-dependent antioxidant activity in the (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging assay Conclusions The water extract of Anabasis setifera . exhibits significant anti-angiogenic and antioxidant activities and may represent a promising natural source angiogenesis agents .

Keywords

References

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