One of the most interesting pharmaceutical drug delivery systems with minimally invasive technique are Microneedles. In the recent years, many researchers have concluded that Microneedles can be a leading method in the future. As a drug delivery system, Microneedles can improve drug delivery by avoiding many barriers that were linked with the conventional system, these unique properties could make Microneedles widely used. The primary mechanism for improving drug delivery to the targeted site with minimal complications is by creating micro-sized pores in the skin layer. The growing interest of Microneedles in biomedical and pharmaceutical research is obtained by easy delivery of active ingredient with low invasive technique. Vaccines, peptides, and hormones are examples of molecules delivered by Microneedles. In this review, we will discuss Microneedles efficiency as drug delivery carriers, fabrication materials, and several related patents
Diabetic ulcer is a significant medical issue affecting millions of patients globally due to consequential morbidity, mortality, and health care system costs. The complex pathophysiological process of delayed wound healing in diabetic patients remains inadequately addressed with conventional treatment modalities. This review summarises recent advances in smart, responsive engineered drug delivery systems for the treatment of diabetic ulcers. Moreover, we exemplify these strategies using emerging technologies, including nanotechnology, hydrogel matrices, stimulus-responsive systems, and bioactives. New methodologies, including next-generation approaches such as 3D-printed scaffolds, nanofiber systems, and theranostic platforms, are presented as alternative treatment options that could change the landscape of diabetes-related wound care. Discussions on the challenges of translation, regulation, and application of new pharma-technologies in clinical research are offered
Drug delivery methods have evolved to improve therapeutic outcomes, patient compliance, and therapy outcomes. This review examines the historical progression of drug delivery strategies, current innovations, and emerging trends shaping the future of therapeutic approaches. Traditional methods of giving medications, like oral and injection routes, had many problems, such as low bioavailability and systemic side effects. This review looks at how drug delivery systems have changed throughout several drug development eras. It focuses on new developments such as nanotechnology-based delivery, biologics, and the creation of smart drug delivery systems. This review highlights breakthroughs in controlled-release systems, nanocarriers, transdermal patches, and implantable drug-delivery devices, comparing both conventional and modern strategies. Further, advances in microencapsulation technology, gene therapy delivery strategies, and AI-assisted drug formulation are examined in the context of precision and efficacy. These innovations reflect a paradigm shift toward precision medicine with personalized drug delivery strategies minimizing side effects while maximizing therapeutic outcomes. Importantly, nanomedicine and biological therapies have successfully addressed critical challenges of drug stability, bioavailability, and drug delivery mechanisms for controlled release devices