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Go to Editorial ManagerDiabetic ulcer is a significant medical issue affecting millions of patients globally due to consequential morbidity, mortality, and health care system costs. The complex pathophysiological process of delayed wound healing in diabetic patients remains inadequately addressed with conventional treatment modalities. This review summarises recent advances in smart, responsive engineered drug delivery systems for the treatment of diabetic ulcers. Moreover, we exemplify these strategies using emerging technologies, including nanotechnology, hydrogel matrices, stimulus-responsive systems, and bioactives. New methodologies, including next-generation approaches such as 3D-printed scaffolds, nanofiber systems, and theranostic platforms, are presented as alternative treatment options that could change the landscape of diabetes-related wound care. Discussions on the challenges of translation, regulation, and application of new pharma-technologies in clinical research are offered
Objective: Angiogenesis is the formation of new blood vessels from pre-existing vasculature, a basic and tightly controlled biological process. Angiogenesis is essential for tissue regeneration, wound healing, and embryonic development under normal physiological conditions. However, under pathological conditions, dysregulated angiogenesis contributes to several diseases, including cancer, making it an important therapeutic target. Accordingly, natural products, including Capparis spinosa L. have attracted considerable attention as promising anti-angiogenic agents. C. spinosa is rich in bioactive phytochemicals such as flavonoids and phenolic compounds that have been reported to possess anti-angiogenic potential. This study aimed to evaluate the anti-angiogenic and antioxidant activities of Capparis spinosa leaf extracts using complementary ex vivo and in vivo models. Methods: The rat aortic ring anti-angiogenesis assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, and chick chorioallantoic membrane (CAM) assay were carried out in the tissue culture laboratory of the Department of Pharmacology, College of Pharmacy, Al-Nahrain University. Results: The ethanolic extract demonstrated significant inhibition of microvessel outgrowth in the rat aortic ring assay, with an IC₅₀ value of 16.2 µg/mL and reduced neovascularisation in the CAM model, with an inhibition zone of 12±1.83 mm. The extract also exhibited concentration-dependent antioxidant activity in the DPPH assay. Conclusions: The ethanolic extract of Capparis spinosa L. exhibits significant anti-angiogenic and antioxidant activities and represents a promising natural source of compounds capable of modulating angiogenesis and oxidative stress, supporting its potential therapeutic applications.