Abstract
Background: Volkameria inermis is a medicinal plant traditionally used for its antimicrobial, anti-inflammatory, and antioxidant properties. Owing to the increasing resistance of pathogenic bacteria to conventional antibiotics, there is a growing interest in exploring plant-derived compounds as alternative therapeutic agents. Objectives: The objective of this study was to assess the effectiveness of an ethanolic extract of Volkameria inermis leaves by using an ethanolic solvent that was eighty percent strength. Methods: Samples of leaves were gathered from the center area of Iraq (Al-Musayab), and washed, sorted, and dried in a shaded environment. Through the use of 800 milliliters of 80% ethanol, an extract of Volkameria inermis leaves was created and dried using a rotary evaporator, it was stored in petri dishes that had been sterilized, and one milligram of the extract was dissolved in one milliliter of dimethyl sulfoxide (DMSO). To conduct the antibacterial test using the agar well diffusion technique, the solution was serially diluted to a concentration of 1 mg/ml. The efficacy of an ethanol extract against bacteria as assessed by well diffusion method. Results: When tested against both (Staphylococcus aureus) and (Salmonella typhi) bacteria, the ethanolic extract of Volkameria inermis demonstrated a notable antibacterial effect at a concentration of 500 μg/ml, which resulted in more inhibition zones than the antibiotic ciprofloxacin. Conclusion: The outcomes of this study demonstrated that the Volkameria inermis plant outperformed the drug ciprofloxacin in its antibacterial activity against Staphylococcus aureus and Salmonella typhi.